Never have, myself. Pretty much only ever rent cars when I/we fly somewhere.
We end up putting ~25k per year on our family/trip car, and just kind of consider it part of enjoying to travel and seeing family regularly (we’re a family of 5, so rarely fly due to the cost). We buy new (or newish) vehicles for this, and shoot to keep them 8 years/200k miles.
For those who have done this or do it regularly, what’s your main reasoning? If mainly financial, do it seem to work out in your favor to rent, and not rack up those miles on your vehicle?